Atomic Email Hunter 4.60 13

we hypothesized that the mechanism of antibody distribution to different tissues is distinct from one anatomical location to the next. each tissue consists of a unique set of cells and structures that differ from the others. to test this hypothesis we need to evaluate if one tissue is more permeable to the molecules of interest than others. a tissue that is permeable is mobile and allows the molecule of interest to move across tissue boundaries. if the molecule of interest diffuses as predicted by the ficks law, the antibody distribution should correspond to the anatomical site it was injected at. a tissue that restricts diffusion will not allow the molecule of interest to move at the site it was injected at. using lsm we show that the distribution of antibody in the body correlates to the anatomical site of injection rather than to the tissue type of the site.

atomic email hunter 4.60 13

to analyze ab distribution in different organs, a method is required to accurately measure the location of the molecule of interest. we developed a systematic approach to test if ab is distributed in the expected anatomical sites and to evaluate the relative ab distribution between organs. our method is able to detect clear differences in the distribution of ab between different organs. using this new technology, our future work will be to scale it to determine the distribution of ab in other biological systems. finally we aim to test if immunotherapy that is currently moving through clinical trials will be effective in treating cancer. using this new ab tracking method we will be able to test this hypothesis.

https://www.itzagud.com/group/stexico/discussion/a76d7f2f-5296-4a12-9895-ba4edf89a21e